CB1565

CHO-K1 IndSTEAP1

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndSTEAP1 is an IndEx-2 stable cell line inducibly expressing full length human STEAP1.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells product on a white background
  • Packaging of Rouken Cells product on a white background
Packaging of Rouken Cells product on a white background
Specification
Inducible Receptor
STEAP1
CD Designation
STEAP1
Gene name
STEAP1
Aliases
STEAP1, Six-transmembrane epithelial antigen of prostate 1
Uniprot ID
Q9UHE8
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
STEAP1 encodes a six-transmembrane cell surface protein located on chromosome 7q21. It is normally expressed at low levels in prostate tissue and testis but is strongly upregulated in prostate cancer and other solid tumours. Although its precise function is not fully defined, STEAP1 has been implicated in metal ion metabolism and intercellular communication.

Therapeutic strategies targeting STEAP1 include antibody-drug conjugates, radioligand therapies, and CAR-T cells, with the aim of selectively targeting STEAP1-positive cancers such as castration-resistant prostate cancer.

Performance Data

Figure 1 – Histograms of STEAP1 Induction at 0-100 µM Inducer.

Figure 2 – Quantification of STEAP1 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

Download PDF

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