CB1563

CHO-K1 IndPD-L1

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndPD-L1 is an IndEx-2 stable cell line inducibly expressing full length human PD-L1.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells CHO-K1 IndPDL1 on a white background
Graph showing PD-L1 expression with different inducer concentrations on a white background
  • Packaging of Rouken Cells CHO-K1 IndPDL1 on a white background
  • Graph showing PD-L1 expression with different inducer concentrations on a white background
Packaging of Rouken Cells CHO-K1 IndPDL1 on a white background
Graph showing PD-L1 expression with different inducer concentrations on a white background
Specification
Inducible Receptor
PD-L1
CD Designation
CD274
Gene name
CD274
Aliases
CD274, B7-H1
Uniprot ID
Q9NZQ7
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
PD-L1, encoded by the CD274 gene on chromosome 9p24, is a type I transmembrane protein and a major ligand for PD-1. It is inducibly expressed on immune cells and constitutively expressed on many tumour cells. PD-L1 binding to PD-1 suppresses T-cell activity, fostering immune escape.
Overexpression of PD-L1 is observed in lung cancer, melanoma, renal cell carcinoma, and many other cancers, where it correlates with aggressive disease biology. PD-L1 inhibitors (e.g., atezolizumab, durvalumab, avelumab) are widely used to block the PD-1/PD-L1 axis, reactivating antitumour immunity.
Performance Data
Graph showing PD-L1 expression with different inducer concentrations on a white background

Figure 1 – Histograms of PD-L1 Induction at 0-100 µM Inducer

Figure 2 – Quantification of PD-L1 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

Download PDF

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