CB1546

CHO-K1 IndMUC16ecd

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndMUC16ecd is an IndEx-2 stable cell line inducibly expressing the extracellular domain of MUC16 (amino acids 13,785-14,507).

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

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  • Rouken Cells packaging with text on a white background
Rouken Cells packaging with text on a white background
Specification
Inducible Receptor
MUC16ecd
CD Designation
N/A
Gene name
MUC16
Aliases
MUC16, Mucin 16, CA125
Uniprot ID
Q8WXI7 (amino acids 13,785-14,507)
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
MUC16, encoded by the MUC16 gene on chromosome 19p13.2, is a high–molecular weight transmembrane mucin glycoprotein and a major component of the epithelial glycocalyx. It is best known as the source of the cancer antigen CA125, widely used as a biomarker in ovarian cancer. Structurally, MUC16 consists of a large extracellular domain with tandem repeat regions, a transmembrane segment, and a short cytoplasmic tail that mediates intracellular signalling.

Physiologically, MUC16 contributes to epithelial barrier function and protection against pathogens on mucosal surfaces such as the respiratory and reproductive tracts. In cancer, overexpression and altered glycosylation of MUC16 promote tumourigenesis through enhanced cell adhesion, immune evasion, and activation of signalling pathways including JAK/STAT and PI3K/AKT. MUC16 overexpression is characteristic of ovarian, pancreatic, and breast carcinomas and is associated with poor prognosis.

The CHO-K1 IndEx-2 cell line expresses the extracellular domain of MUC16, corresponding to amino acids 13,785-14,507.
Performance Data

Figure 1 – Histograms of Muc16ecd Induction at 0-100 µM Inducer.

Figure 2 – Quantification of Muc16ecd Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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