CB1581

CHO-K1 IndLRRC15

£5,000.00
£5,000.00
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CHO-K1 IndLRRC15 is an IndEx-2 stable cell line inducibly expressing full length human LRRC15.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Specification
Inducible Receptor
LRRC15
CD Designation
LRRC15
Gene name
LRRC15
Aliases
LRRC15, Leucine rich repeat containing 15
Uniprot ID
Q8TF66
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
LRRC15 is a type I transmembrane protein encoded on chromosome 10q23. It belongs to the leucine-rich repeat (LRR) superfamily and is involved in cell adhesion and extracellular matrix interactions. Under normal conditions, LRRC15 is expressed in mesenchymal and stromal cells but is strongly induced in cancer-associated fibroblasts (CAFs).
LRRC15 contributes to the immunosuppressive tumour microenvironment and is associated with tumour progression and metastasis. It has emerged as a target in solid tumours, particularly sarcoma, breast cancer, and glioblastoma. Therapeutic strategies include antibody-drug conjugates such as ABBV-085 and potential combinations with checkpoint inhibitors.
Performance Data

Figure 1 – Histograms of LRRC15 Induction at 0-100 µM Inducer.

Figure 2 – Quantification of LRRC15 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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