CB1502

CHO-K1 IndHer2

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndHer2 is an IndEx-2 stable cell line inducibly expressing full length human Her2.

FOR RESEARCH USE ONLY

Rouken Cells product packaging on a white background
  • Rouken Cells product packaging on a white background
Rouken Cells product packaging on a white background
Specification
Inducible Receptor
Her2
CD Designation
CD340
Gene name
ERBB2
Aliases
CD340, ERBB2, MLN19, NEU, NGL
Uniprot ID
P04626
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
HER2 is a receptor tyrosine kinase belonging to the epidermal growth factor receptor (EGFR) family, encoded by the ERBB2 gene located on chromosome 17q12. Unlike other EGFR family members, HER2 does not have a known ligand and functions primarily through heterodimerisation with other ErbB receptors, activating downstream signalling pathways such as MAPK, PI3K/AKT, and JAK/STAT, which promote cell proliferation and survival. HER2 is amplified or overexpressed in approximately 15–20% of breast cancers, as well as in subsets of gastric, esophageal, ovarian, and bladder cancers. HER2 overexpression is associated with aggressive tumour biology and poor prognosis in the absence of targeted therapy. The development of HER2-targeted treatments such as trastuzumab, pertuzumab, trastuzumab emtansine (T-DM1), and trastuzumab deruxtecan (T-DXd) has significantly improved outcomes in HER2-positive cancers. HER2 is also being explored as a target in other modalities, including bispecific antibodies, CAR-T cells, and vaccines.
Performance Data

Figure 1 – Histograms of HER2 Induction at 0-10 µM Inducer.

Figure 2 – Quantification of HER2 Induction at 0-10 µM ABA.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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