CB1557

CHO-K1 IndEpCAM

£5,000.00
£5,000.00
Tax included.
Out of Stock

CHO-K1 IndEpCAM is an IndEx-2 stable cell line inducibly expressing full length human EpCAM.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells product on a white background
  • Packaging of Rouken Cells product on a white background
Packaging of Rouken Cells product on a white background
Specification
Inducible Receptor
EpCAM
CD Designation
CD326
Gene name
EPCAM
Aliases
CD326, EPCAM, TACSTD1
Uniprot ID
P16422
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
EpCAM is a type I transmembrane glycoprotein encoded by the EPCAM gene, located on chromosome 2p21. It functions primarily in cell-cell adhesion, proliferation, differentiation, and intracellular signalling. While normally expressed in many epithelial tissues, EpCAM is upregulated in a wide range of epithelial-derived tumours, including colorectal, breast, ovarian, prostate, pancreatic, and lung cancers. Overexpression of EpCAM is often associated with cancer stem cell properties, increased proliferation, and poor prognosis. Its widespread and high expression in tumour cells, coupled with relatively low expression in non-proliferating normal epithelia, makes it an attractive target for immunotherapy. EpCAM has been targeted using monoclonal antibodies (e.g., catumaxomab), bispecific T-cell engagers, and CAR-T cell therapies. Additionally, it is widely used as a marker for circulating tumour cells (CTCs) in liquid biopsy platforms. Despite its therapeutic potential, targeting EpCAM requires caution due to its expression in some normal tissues, which may lead to on-target/off-tumour toxicity.
Performance Data

Figure 1 – Histograms of EpCAM Induction at 0-100 µM Inducer.

Figure 2 – Quantification of EpCAM Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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