CB1506

CHO-K1 IndDLL3

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndDLL3 is an IndEx-2 stable cell line inducibly expressing full length human DLL3.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells product on a white background
  • Packaging of Rouken Cells product on a white background
Packaging of Rouken Cells product on a white background
Specification
Inducible Receptor
DLL3
CD Designation
N/A
Gene name
DLL3
Aliases
DLL3, Delta-like protein 3
Uniprot ID
Q9NYJ7
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
DLL3 is an inhibitory ligand in the Notch signalling pathway, encoded by the DLL3 gene. Unlike other Notch ligands, DLL3 does not activate Notch receptors but instead functions to inhibit the pathway intracellularly. It is minimally expressed in normal adult tissues but is highly upregulated in high-grade neuroendocrine tumours, particularly small cell lung cancer (SCLC). Due to its tumour-selective expression, DLL3 has been explored as a target for ADCs, including rovalpituzumab tesirine (Rova-T), and is under investigation for CAR-T therapies and bispecific antibodies.
Performance Data

Figure 1 – Histograms of DLL3 Induction at 0-100 µM Inducer.

Figure 2 – Quantification of DLL3 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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