CB1579

CHO-K1 IndDLK1

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndDLK1 is an IndEx-2 stable cell line inducibly expressing full length human DLK1.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells product on a white background
  • Packaging of Rouken Cells product on a white background
Packaging of Rouken Cells product on a white background
Specification
Inducible Receptor
DLK1
CD Designation
DLK1
Gene name
DLK1
Aliases
DLK1, Pref-1
Uniprot ID
P80370
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
DLK1 is a transmembrane protein belonging to the Notch/Delta family, encoded by the DLK1 gene on chromosome 14q32. It is an atypical Notch ligand that lacks the canonical DSL domain and functions as a regulator of differentiation in multiple tissues, including adipose, hematopoietic, and neuroendocrine systems.
In cancer, DLK1 is frequently re-expressed and overexpressed, particularly in hepatocellular carcinoma, neuroblastoma, and gliomas. It is implicated in maintaining tumour stemness, inhibiting differentiation, and promoting proliferation. Its restricted expression in adult tissues but strong presence in tumours makes DLK1 a potential therapeutic target. Experimental approaches include monoclonal antibodies and CAR-T therapies directed against DLK1, with early studies suggesting potential in targeting tumour-initiating cells.
Performance Data

Figure 1 – Histograms of DLK1 Induction at 0-100 µM Inducer.

Figure 2 – Quantification of DLK1 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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