CB1529

CHO-K1 IndcMET

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndcMET is an IndEx-2 stable cell line inducibly expressing full length human cMET.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Graph showing cMET receptor expression per cell against inducer concentration in logarithmic scale.
Graph showing cMET expression with inducer concentration on a white background
  • Graph showing cMET receptor expression per cell against inducer concentration in logarithmic scale.
  • Graph showing cMET expression with inducer concentration on a white background
Graph showing cMET receptor expression per cell against inducer concentration in logarithmic scale.
Graph showing cMET expression with inducer concentration on a white background
Specification
Inducible Receptor
cMET
CD Designation
CD340
Gene name
MET
Aliases
CD340, MET, HGFR
Uniprot ID
P08581
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
c-MET is a receptor tyrosine kinase encoded by the MET gene and is the receptor for hepatocyte growth factor (HGF). It plays a pivotal role in cellular processes such as proliferation, motility, survival, and angiogenesis. Aberrant c-MET activation—through overexpression, amplification, or mutations—has been implicated in several cancers, including NSCLC, gastric cancer, renal cell carcinoma, and hepatocellular carcinoma. Therapeutic agents targeting c-MET include tyrosine kinase inhibitors (TKIs) such as crizotinib and capmatinib, as well as monoclonal antibodies and ADCs in development.
Performance Data
Graph showing cMET expression with inducer concentration on a white background

Figure 1 – Histograms of cMET Induction at 0-100 µM Inducer.

Graph showing cMET receptor expression per cell against inducer concentration in logarithmic scale.

Figure 2 – Quantification of cMET Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

Download PDF

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