CB1510

CHO-K1 IndCLDN3

£5,000.00
£5,000.00
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CHO-K1 IndCLDN3 is an IndEx-2 stable cell line inducibly expressing full length human CLDN3.

FOR RESEARCH USE ONLY

Rouken Cells product packaging on a white background
Graph showing the expression of CLDN3 protein with varying inducer concentrations, labeled 'Non-Induced' and 'CHO-K1 parental'.
Graph showing CLDN3 receptor concentration per cell against inducer concentration in micromolar units.
  • Rouken Cells product packaging on a white background
  • Graph showing the expression of CLDN3 protein with varying inducer concentrations, labeled 'Non-Induced' and 'CHO-K1 parental'.
  • Graph showing CLDN3 receptor concentration per cell against inducer concentration in micromolar units.
Rouken Cells product packaging on a white background
Graph showing the expression of CLDN3 protein with varying inducer concentrations, labeled 'Non-Induced' and 'CHO-K1 parental'.
Graph showing CLDN3 receptor concentration per cell against inducer concentration in micromolar units.
Specification
Inducible Receptor
CLDN3
CD Designation
CLDN3
Gene name
CLDN3
Aliases
CLDN3, Claudin-3
Uniprot ID
Q15551
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
Claudin-3 is a member of the claudin family of tight junction proteins, encoded by the CLDN3 gene. It plays a vital role in maintaining epithelial cell polarity and barrier function by regulating paracellular transport. In normal tissues, CLDN3 expression is typically restricted to specific epithelial surfaces. However, it is frequently overexpressed in various cancers, particularly ovarian, prostate, breast, pancreatic, and lung adenocarcinomas. This overexpression is often associated with loss of tight junction integrity and increased tumour invasiveness. CLDN3 is located on chromosome 7q11.23, a region frequently amplified in cancers. Due to its cell surface localization and elevated expression in tumours, CLDN3 has been explored as a target for antibody-based therapies, including monoclonal antibodies and antibody-drug conjugates (ADCs), as well as Clostridium perfringens enterotoxin (CPE)-based approaches, which exploit the ability of the enterotoxin to bind claudin family members and induce tumour cell lysis.
Performance Data
Graph showing the expression of CLDN3 protein with varying inducer concentrations, labeled 'Non-Induced' and 'CHO-K1 parental'.

Figure 1 – Histograms of CLDN3 Induction at 0-100 µM Inducer.

Graph showing CLDN3 receptor concentration per cell against inducer concentration in micromolar units.

Figure 2 – Quantification of CLDN3 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

Download PDF

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