CB1508

CHO-K1 IndCEACAM5 (Luc2)

£5,000.00
£5,000.00
Tax included.
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CHO-K1 IndCEACAM5 (Luc2) is an IndEx-2 stable cell line inducibly expressing full length human CEACAM5. The cell line also constitutively expresses firefly luciferase.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells product on a white background.
  • Packaging of Rouken Cells product on a white background.
Packaging of Rouken Cells product on a white background.
Specification
Inducible Receptor
CEACAM5
CD Designation
CD66e
Gene name
CEACAM5
Aliases
CD66e, CEACAM5, CEA
Uniprot ID
P06731
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
CEACAM5, also known as CEA, is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein encoded by the CEACAM5 gene on chromosome 19q13. Belonging to the immunoglobulin superfamily, CEACAM5 mediates cell adhesion and signalling. Physiologically, it is expressed during foetal development but is largely absent from adult tissues, aside from low levels in the colon and gastrointestinal tract.
CEACAM5 is re-expressed and highly upregulated in colorectal, pancreatic, gastric, and non-small cell lung cancers, where it plays a role in tumour progression, metastasis, and immune evasion. Clinically, CEACAM5 has long been used as a tumour biomarker (CEA levels) for cancer diagnosis and monitoring. Therapeutically, CEACAM5 is being targeted by antibody-drug conjugates (e.g., tusamitamab ravtansine), bispecific antibodies, and CEA-directed CAR-T therapies, showing promise in solid tumour treatment.
Performance Data

Figure 1 – Histograms of CEACAM5 Induction at 0-100 µM Inducer.

Figure 2 – Quantification of CEACAM5 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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