CB1556

CHO-K1 IndBCMA

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndBCMA is an IndEx-2 stable cell line inducibly expressing full length human BCMA.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells with text on a white background
  • Packaging of Rouken Cells with text on a white background
Packaging of Rouken Cells with text on a white background
Specification
Inducible Receptor
BCMA
CD Designation
CD269
Gene name
TNFRSF17
Aliases
CD269, TNFRSF17, BCM
Uniprot ID
Q02223
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
BCMA is a member of the tumour necrosis factor receptor superfamily, encoded by the TNFRSF17 gene. It plays a critical role in B-cell maturation, survival, and differentiation into plasma cells through binding to ligands such as BAFF and APRIL. BCMA is highly and selectively expressed on malignant plasma cells in multiple myeloma, with minimal expression on normal tissues, which has led to its successful targeting by CAR-T cell therapies (e.g., idecabtagene vicleucel), bispecific antibodies, and ADCs (e.g., belantamab mafodotin). Its restricted expression pattern and immunogenic profile make it a leading antigen in the treatment of multiple myeloma.
Performance Data

Figure 1 – Histograms of BCMA Induction at 0-100 µM Inducer.

Figure 2 – Quantification of BCMA Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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