CB1594

CHO-K1 IndB7-H3

£5,000.00
£5,000.00
Tax included.
In Stock

CHO-K1 IndB7-H3 is an IndEx-2 stable cell line inducibly expressing full length human B7-H3.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Packaging of Rouken Cells with product details on a white background.
  • Packaging of Rouken Cells with product details on a white background.
Packaging of Rouken Cells with product details on a white background.
Specification
Inducible Receptor
B7-H3
CD Designation
CD276
Gene name
CD276
Aliases
CD276, B7 homolog 3
Uniprot ID
Q5ZPR3
Receptor Species
Homo sapiens
Cell Line Background
CHO-K1
Target Information and Further Details
B7-H3 is a type I transmembrane protein and a member of the B7 family of immune checkpoint molecules. It plays a complex role in immune regulation, generally thought to inhibit T-cell activation, although some studies suggest a co-stimulatory role under certain conditions. The CD276 gene is frequently overexpressed in a wide range of solid tumours, including prostate, breast, non-small cell lung cancer (NSCLC), and glioblastoma, while its expression is limited in normal tissues. This tumour-restricted expression makes B7-H3 an attractive target for antibody-drug conjugates (ADCs), CAR-T cells, and other immunotherapeutic strategies.
Performance Data

Figure 1 – Histograms of B7-H3 Induction at 0-100 µM Inducer.

Figure 2 – Quantification of B7-H3 Induction at 0-100 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

* Please note that US import permits for CHO-K1 cell products are the responsibility of the US-based recipient/importer. RoukenCells is happy to provide supporting documentation (e.g. product descriptions and noninfectious statements) to assist with the import process.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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