CB1580

A549 IndFOLR1

£5,000.00
£5,000.00
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A549 IndFOLR1 is an IndEx-2 stable cell line inducibly expressing full length human FOLR1.

IndEx-2 is RoukenCells' proprietary inducible expression system that enables precise, dose-dependent control of one or two target antigens within your chosen cell line. Using orthogonal chemically induced proximity switches, antigen expression can be independently tuned across a biologically relevant range, creating custom cell models for target validation, assay development and therapeutic screening.

Download our technical presentation here for more information and case studies.

FOR RESEARCH USE ONLY

Specification
Inducible Receptor
FOLR1
CD Designation
FOLR1
Gene name
FOLR1
Aliases
FOLR1, Folate receptor alpha, FRα
Uniprot ID
P15328
Receptor Species
Homo sapiens
Cell Line Background
A549
Target Information and Further Details
FOLR1 encodes folate receptor alpha, a glycosylphosphatidylinositol (GPI)-anchored protein located on chromosome 11q13. It binds and internalizes folates via endocytosis, playing a role in folate transport. Normal expression is limited to specific epithelial tissues such as the kidney, lung, and placenta.
In cancer, FOLR1 is highly expressed in ovarian, endometrial, and some lung adenocarcinomas, where it supports tumour growth and survival. Its tumour-restricted expression pattern makes it an appealing target. Therapies under development include antibody-drug conjugates (e.g., mirvetuximab soravtansine), bispecific antibodies, and CAR-T cells, which exploit FOLR1’s high surface expression for selective tumour killing.
Performance Data

Figure 1 – Histograms of FOLR1 Induction at 0-200 µM Inducer.

Figure 2 – Quantification of FOLR1 Induction at 0-200 µM Inducer.

* Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for preclinical research and development use only.

Shipping Details

Supplied as 1 vial of >3 million viable cells.

Cell Line Datasheet

Access detailed product specifications, user guides and technical documentation in PDF format.

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